- as Wade Wilson / Deadpool
- as Juggernaut (Voice)
- as Nathan Summers / Cable
- as Vanessa
- as Russell Collins / Firefist
- as Neena Thurman / Domino
- as Weasel
- as Blind Al
- as Dopinder
- as Negasonic Teenage Warhead
- as Black Tom
- as Headmaster
- as Yukio
- as Colossus (Voice)
- as Buck
- as Head Orderly Frye
- as Sergei Valishnikov
- as Peter
- as Shatterstar
- as Zeitgeist
- as Bedlam
- as Vanisher (Cameo)
- as Hong Kong Boss
- as Sluggo
- as Redneck #2 (Cameo)
- as Luke - Redneck #1 (Cameo)
- as Swat Captain (School)
- as Bus Driver
- as Cable's Wife
- as Cable's Daughter
- as Tree Trimmer #1
- as Tree Trimmer #2
- as Prison Guard
- as Cereal Kid
- as Neighbour #1
- as Neighbour #2
- as Neighbour #3
- as Branding Boy
- as Older Firefist
- as News Reporter (Irene)
- as News Cameraman (Cameo)
- as News Helicopter Pilot (Cameo)
- as Chinook Pilot
- as Black Tom Gang Member
- as Priest
- as Park Bench Couple
- as Park Bench Couple
- as Ground Church Mutant (Cameo)
- as Vocalist on 'Tomorrow' (Voice)
- as Beast (Cameo)
- as Charles Xavier (Cameo)
- as Quicksilver (Cameo)
- as Cyclops (Cameo)
- as Storm (Cameo)
- as Nightcrawler (Cameo)
- as Wolverine (Archive footage)
- as Ryan Reynolds (Cameo)
- as Fred Savage
Watch "Deadpool 2":