The winner of several AVN Awards, she has spent most of her career as a contract performer with major producer Vivid Entertainment, and is known for her roles in acclaimed adult films such as The New Devil in Miss Jones. In addition to performing, she has her own adult film studio, Savanna Samson Productions. A native of upstate New York, she entered the adult film industry in 2000, after working as a dancer at the Manhattan strip club, Scores.

Samson has gained mainstream recognition with appearances on television shows such as Saturday Night Live, The Daily Show and 30 Rock. Her wide range of activities outside pornography include working as a sex-advice columnist, a radio presenter and a political correspondent. She also produces her own line of wines, has a recording contract with E1 Music and is a trained ballerina.