- as Sheldon Cooper
- as Mandy McAllister
- as Mary Cooper
- as Dr. Linkletter
- as President Hagemeyer
- as George Cooper, Sr.
- as George Cooper Jr.
- as Gary
- as Missy Cooper
- as Audrey
- as Connie 'Meemaw' Tucker
- as Toby
- as Sheldon Cooper (Voice)
- as Dr. Nicholson
- as Dr. Sturgis
- as Barbara
- as Doreen
- as Carl
- as Carlos
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