- as Lieutenant Matthew „Matt“ Casey
- as Clarice
- as Lieutenant Kelly Severide
- as Jose Vargas
- as Peter Mills
- as Joe Cruz
- as Otis
- as Gabriela „Gabby“ Dawson
- as Leslie Elizabeth Shay
- as Mouch
- as Chief Wallace Boden
- as Elise Mills
- as Lieutenant Christopher Herrmann
- as Ingrid Mills
- as Hallie Thomas
- as Christie
- as Capp
- as Hadley
- as Dr. Kendra
- as Corrinne
- as Jacob
- as Gary
- as Jim
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