- as Sheldon Cooper
- as Connie 'Meemaw' Tucker
- as Mary Cooper
- as Sheldon Cooper (Voice)
- as George Cooper, Sr.
- as Dr. Linkletter
- as George Cooper Jr.
- as Ralph
- as Missy Cooper
- as Brenda Sparks
- as Veronica Duncan
- as Jana
- as Dr. John Sturgis
- as Carol
- as Sally
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