- as Sheldon Cooper
- as Pastor Jeff
- as Mary Cooper
- as Dr. Linkletter
- as George Cooper, Sr.
- as Brenda Sparks
- as George Cooper Jr.
- as Mr. Givens
- as Missy Cooper
- as Ms. Hutchins
- as Connie 'Meemaw' Tucker
- as Tam
- as Sheldon Cooper (Voice)
- as Dr. John Sturgis
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Watch "Young Sheldon > A Box of Treasure and the Meemaw of Science":