- as John Grogan
- as Jenny Grogan
- as Sebastian Tunney
- as Ms. Kornblut
- as Arnie Klein
- as Patrick Grogan (Age 10)
- as Lisa
- as Dr. Platt
- as Editor
- as Conor (Age 8)
- as Patrick (Age 7)
- as Conor (Age 5)
- as Big Guy
- as Debby
- as Dr. Sherman
- as Jorge
- as Lori
- as Mrs. Butterly
- as OB-GYN Nurse
- as Viviana
- as Dude
- as Still Photographer
- as Himself
- as Herself
- as Cocker Spaniel Owner (Cameo)
- as The Police Officer
Watch "Marley & Me":