Tucci, an Italian American, was born in Katonah, New York, the daughter of Joan (née Tropiano), a retired secretary and writer, and Stanley Tucci, Sr., a retired high school art teacher. Her brother is actor Stanley Tucci, and her cousin is screenwriter Joseph Tropiano.

Tucci had a semi-regular role on the television series MDs (2002) and played Amanda Cory on the soap opera Another World from 1993 to 1995. She played Sergeant Welles in the movie K-911, released direct-to-video in 1999; in 2000, she made an appearance as Dr. Kiera Behrle on CSI: Crime Scene Investigation. She is sometimes credited as 'Christina Tucci'.

Tucci is married to actor Vincent Angell. She has one son with Angell, who has autism. Coincidentally, both Angell and Tucci played parents of an autisic boy on an episode of “Without a Trace”.