- as Sheldon Cooper
- as June
- as Mary Cooper
- as President Hagemeyer
- as George Cooper, Sr.
- as Brenda Sparks
- as George Cooper Jr.
- as Paige Swanson
- as Missy Cooper
- as Linda
- as Connie 'Meemaw' Tucker
- as Coach Wilkins
- as Sheldon Cooper (Voice)
- as Dr. John Sturgis
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