- as Sheldon Cooper
- as Mandy
- as Mary Cooper
- as Principal Petersen
- as George Cooper, Sr.
- as Coach Wilkins
- as George Cooper Jr.
- as Jake
- as Missy Cooper
- as Darlene Wilkins
- as Connie 'Meemaw' Tucker
- as Sheldon Cooper (Voice)
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Watch "Young Sheldon > An Ugly Car, an Affair and Some Kickass Football":