- as Sheldon Cooper
- as A.V.
- as Mary Cooper
- as Pus
- as George Cooper, Sr.
- as Dr. Linkletter
- as George Cooper Jr.
- as President Hagemeyer
- as Missy Cooper
- as Brenda Sparks
- as Connie 'Meemaw' Tucker
- as Principal Petersen
- as Sheldon Cooper (Voice)
- as Roy
- as Coach Wayne Wilkins
- as Wade
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